Unlocking Excellence in HPLC: AiBST’s Immersive Training Elevates Analytical Science

AIBST Therapeutics team completed a two-week training in High-Performance Liquid Chromatography (HPLC) designed to strengthen analytical capabilities, safeguard data integrity, and elevate the quality of our drug discovery and development research.

Why HPLC Training Matters

In the fast-paced world of pharmaceutical research, precision matters. HPLC is a cornerstone technique for separating, identifying, and quantifying compounds in complex samples. By investing in hands-on training, AiBST ensures our scientists:

• Deliver robust, reproducible data that underpins R&D decisions and regulatory submissions.

• Maintain the highest standards of product quality and process understanding.

• Build cross-functional expertise that bridges QA, R&D, and manufacturing.

Key Focus Areas

• HPLC Fundamentals: Mastery of chromatographic separation principles, retention mechanics, and resolution optimization.

• System Mastery: Hands-on experience with HPLC instrumentation, including pumps, autosampler, column oven, detector, and ChemStation software.

• Method Development: Designing both isocratic and gradient methods, selecting mobile phases, choosing columns, and setting detection wavelengths.

• Data Quality: Interpreting chromatograms, evaluating retention times, peak symmetry, and resolution to ensure accurate conclusions.

• Good Laboratory Practices: Calibration, system suitability testing, troubleshooting, and preventive maintenance to sustain instrument performance.

Acknowledgments

A heartfelt thank you to our trainers, whose expertise propelled this program:

• Dr Keabetswe Masike, Drug Discovery and Development Centre (H3D), University of Cape Town

• Dr Darren Edwards, University of Dundee Drug Discovery and Development Centre (H3D)

• Alex Brown, University of Dundee Drug Discovery and Development Centre (H3D)

Their guidance bridged theory and practice, empowering AiBST scientists to push the boundaries of analytical excellence.

What’s Next

Armed with new skills, AiBST will apply these insights to ongoing research with a continued emphasis on:

• Method optimization to enhance sensitivity and robustness

• Real-sample analysis to translate theory into real-world results

• Knowledge sharing across scientific teams to amplify impact and innovation

Impact Across AiBST and Beyond

• Research Integrity: Stronger data trustworthiness supports robust conclusions and credible regulatory submissions.

• Cross-Functional Collaboration: Enhanced collaboration between QA, R&D, and manufacturing accelerates development timelines.

• Industry Relevance: Alignment with best practices in analytical chemistry ensures AiBST remains at the vanguard of drug discovery and development.

Collaborations and Partnerships

We gratefully acknowledge the partnerships that make advanced training possible:

• University of Cape Town

• University of Dundee Drug Discovery and Development Centre (H3D)

• Gates Foundation

  
  

Join Us on the Journey

As AiBST continues to invest in world-class training and cutting-edge instrumentation, we remain committed to delivering rigorous science, reliable data, and innovative solutions that accelerate drug discovery and development. The knowledge gained today paves the way for tomorrow’s breakthroughs.